Agglutination of Mammalian Erythrocytes by Newcastle Disease Virus.

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Abstract
The ability of NDV to induce agglutination of mammalian erythrocytes of certain spp. is a character possessed by some but not all strains of the virus. The erythrocytes of certain individuals of such spp. as the cow, the horse, and the sheep are more susceptible than those of others to agglutination by NDV. Agglutination of mammalian red blood cells, as a rule, may be recorded accurately as the % of individuals whose cells are susceptible to the action of a given strain of NDV and not as a uniformly negative or positive result. This percentage of erythrocyte-susceptible individuals may range from zero in some spp. to 100% in others, but in most spp. lies between these extremes so that its consideration is warranted in every instance. The pH may affect the agglutination of mammalian red blood cells and, consequently, alter the interpretation of the test. If suitable controls of the variables of the test are included and the source of red blood cells is properly selected, many strains of NDV may be differentiated by their mammalian agglutination range or spectrum. The phenomenon of agglutination of mammalian erythrocytes has practical application in maintaining the identity of stock strains of virus and possibly also in determining probable intermingling of the viruses of live vaccines and wild strains in field outbreaks of Newcastle disease.

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