A comparison of the effects of flurazepam on γ-aminobutyric acid mediated depression of cerebellar and cerebral cortical neurons
- 1 June 1981
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 59 (6) , 595-598
- https://doi.org/10.1139/y81-089
Abstract
With standard extracellular recording and microiontophoretic techniques, the effects of flurazepam on γ-aminobutyric acid (GABA) evoked depression of cerebellar and cerebral cortical neurons in rats have been studied. It was found that although flurazepam potentiated the GABA-mediated inhibition of most Purkinje cells (25 of 36), it caused only a weak potentiation of GABA action on some cerebral cortical neurons (14 of 37). The difference between the action of flurazepam in these two structures was statistically significant. The results confirm a previous report that the enhancement of GABA-evoked inhibition by benzodiazepines is more readily elicited on cerebellar cortical neurons than on cerebral cortical neurons.This publication has 2 references indexed in Scilit:
- Benzodiazepines and central inhibitory mechanismsNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1978
- Effects of two benzodiazepines, phenobarbitone, and baclofen on synaptic transmission in the cat cuneate nucleusNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1976