THE MEASUREMENT OF BLOOD FLOW BY THE LOCAL CLEARANCE OF RADIOACTIVE SODIUM

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Abstract
The local clearance of Na24 injd. into skin and muscle was studied. Previous observations that application of an arterial tourniquet checked its removal and release of the tourniquet was followed by a period of increased rate of clearance were confirmed. The rate of removal of Na24 injd. into the skin of the hand was not increased by vasodilatation (produced by indirect heating) but was diminished by reflex vasoconstriction. Intraven. infusion of l-epinephrine produced no significant alteration in the rate of clearance of Na24 injd. into skeletal muscle. The clearance rate in these circumstances did not reflect closely the change in local blood flow to the muscle.