The Relation between Induced Resistance to Penicillin and Oxygen Utilization

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Abstract
A penicillin-resistant variant of Staphylococcus aureus has been obtained which grows more slowly than the sensitive, parent culture and has lost the ability to grow anaerobically. Strains of Streptococcus faecalis, S. mastitidis, and Clostridium welchii, when treated in a similar manner, failed to develop significant resistance to penicillin. It is suggested that organisms that depend on anaerobic processes for their energy supply will not develop appreciable resistance to penicillin.