Passerini multicomponent reaction of protected α-aminoaldehydes as a tool for combinatorial synthesis of enzyme inhibitors
- 17 May 2000
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 11,p. 985-986
- https://doi.org/10.1039/b002027n
Abstract
Three-component Passerini condensation of N-Boc-α-aminoaldehydes with various isocyanides and carboxylic acids leads, after Boc-deprotection/transacylation, to complex peptide-like structures containing an α-hydroxy-β-aminoacid unit or, after oxidation, an α-oxo-β-aminoacid unit.Keywords
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