Effects of Changes in Intraluminal Pressure on Inotropic and Chronotropic Responses of Isolated Mammalian Hearts
- 1 July 1958
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 194 (1) , 197-199
- https://doi.org/10.1152/ajplegacy.1958.194.1.197
Abstract
The effect of increasing the intraluminal pressure in the right heart on the activity of isolated perfused dog hearts and the effect of increasing the intraluminal pressure on the activity of isolated right atria of dogs, rabbits, guinea pigs and albino rats have been studied. It has been observed that there is a direct relationship between the magnitude of intraluminal right atrial pressure and the inotropic and chronotropic responses of the whole heart and right atrium up to certain critical pressures (5–15 mm Hg). Some modifications in this behavior of the hearts due to repeated changes in the intraluminal pressure have also been described. It has been suggested that stretch of the cardiac tissue due to increased intraluminal pressure may cause alterations in membrane metabolism at the pacemaker.Keywords
This publication has 1 reference indexed in Scilit:
- Effect of Stretch on Formation and Conduction of Electrical Impulses in the Isolated Sinoauricular Chamber of Frog's HeartAmerican Journal of Physiology-Legacy Content, 1957