Potent, low molecular weight renin inhibitors containing a C-terminal heterocycle: hydrogen bonding at the active site
- 1 June 1990
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 33 (6) , 1582-1590
- https://doi.org/10.1021/jm00168a009
Abstract
A series of low-nanomolar renin inhibitors containing novel C-terminal heterocycles has been designed by formally cyclizing the C-terminus of a glycol-based inhibitor to the second hydroxyl. Molecular modeling suggests that the heterocyclic oxygen hydrogen bonds as an acceptor to the flap region of renin and that the second hydroxyl in the glycol-based inhibitors behaves similarly.This publication has 10 references indexed in Scilit:
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