ETS‐lung cancer epidemiology: Supportability of misclassification and risk assumptions

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Abstract
The NAS Committee on Passive Smoking used epidemiologic data to estimate the risk of lung cancer associated with ETS exposure. Mathematical models were used to assess the influence of smoking‐ and exposure‐status misclassification. These models and the database for their application are thoroughly examined. For smoking status misclassification, the model is technically sound; for exposure misclassification, the model is empirically logical, but mathematically can require very precise data. Further effort is necessary to compensate for the paucity of data to which the models can be applied.