Absorption of Manganese by the Thyroid Gland of the Guinea Pig

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Abstract
Subcutaneous injection of manganese chloride into the guinea pig caused manganese to accumulate in all organs of the body tested, but the deposition was especially great in the thyroid gland where it began to appear within 30 minutes after administration. Absorption was particularly rapid during the first few hours, but the element continued to accumulate for at least 24 hours. Of the total amount of manganese deposited in the thyroid gland about 70%percnt; accumulated during the first 6 hours. Elimination of manganese from the thyroid, once it began, was rapid. Seventy per cent of the 24 hour accumulation disappeared within 48 hours after the injection; 85%percnt; of it vanished in 96 hours.

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