Cross-reacting material in genetic variants of haemophilia B
- 1 May 1972
- journal article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 25 (5) , 433-436
- https://doi.org/10.1136/jcp.25.5.433
Abstract
Cross-reacting factor IX material (CRM) was immunologically detected in the plasma of 38 normal individuals and 21 out of 22 haemophilia B patients using a rabbit antibody to factor IX. The same reacting material was detected in only nine of these patients using a human antibody. These results indicate that the plasma of the majority of haemophilia B patients contains a protein-lacking biological activity but having antigenic determinants in common with normal factor IX.Keywords
This publication has 19 references indexed in Scilit:
- Factor VIII and IX Variants. Relationship between Haemophilia BM and Haemophilia B+European Journal of Clinical Investigation, 1971
- Factor VIII Detection by Hemagglutination Inhibition: Hemophilia A and von Willebrand's DiseaseScience, 1971
- Immunologic differentiation of classic hemophilia (factor VIII deficiency) and von Willebrand's diseaseJournal of Clinical Investigation, 1971
- IMMUNOLOGICAL DIFFERENTIATION OF THREE TYPES OF HÆMOPHILIA AND IDENTIFICATION OF SOME FEMALE CARRIERSThe Lancet, 1970
- Two Types of Haemophilia (A+ and A−): A Study of 48 CasesBritish Journal of Haematology, 1969
- Hemophilia A: Polymorphism Detectable by a Factor VIII AntibodyScience, 1969
- An investigation of three patients with Christmas disease due to an abnormal type of factor ixJournal of Clinical Pathology, 1968
- Genetic variants of hemophilia B: detection by means of a specific PTC inhibitorJournal of Clinical Investigation, 1968
- HÆMOPHILIA BM: A NEW TYPE OF FACTOR-IX DEFICIENCYThe Lancet, 1967
- ACQUIRED INHIBITORS OF PLASMA FACTOR IX A STUDY OF THEIR INDUCTION, PROPERTIES AND NEUTRALIZATIONThe Lancet Healthy Longevity, 1966