The availability of so-called tranquilizing drugs as adjuncts to the therapy of emotionally disturbed children is of such recent origin that few reviews of their use in this regard have as yet appeared. The present article discusses a tentative classification of these substances, their general effects, probable mode of action and potential hazards. Included is a brief review of the literature concerning the use of the following preparations as tranquilizers for children: chlorpromazine, reserpine, azacyclonol, hydroxyzine and meprobamate. Indications for their use are briefly outlined, as are some of the principles of their effective administration. Emphasis is placed upon the fact that tranquilizing drugs may be useful for the relief of symptoms, but that in the total treatment of emotionally disturbed children all other available means of psychologic management should also be employed.