The Hookworm Problem in the Greater Buenos Aires Area with Particular Reference to the Therapeutic Efficacy of Triclofenol Piperazine

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Abstract
Summary Triclofenol piperazine eliminated Necator infections in 30 patients; egg counts were reduced 82% after one treatment, 96% after two treatments, and 100% after a third. Eighteen patients were cleared by first treatment. In the 12 remaining patients, infections were cleared in 7 by the second treatment and in 5 by the third treatment. Single-dose administration was more satisfactory and was effective after one treatment in 79% of 14 patients. When the dose was divided and given on 2 successive days, treatment was effective in only 44% of 16 patients. Thirteen patients had associated Ascaris infections; 12 of these infections were eliminated by the drug. Drug plus supplementary nutritional therapy resulted in significantly greater increases in weight and hemoglobin than nutritional therapy alone. There were no significant changes in weight or hemoglobin of placebo patients. Four drug-treated patients or 16% had mucous diarrhea; two of these patients had nausea and one had vomiting. These were the only side effects observed. Results from this trial suggest that single-dose treatment with triclofenol piperazine could be used advantageously for mass therapy.

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