DISTRIBUTION AND LOSSES OF PLASMA PROTEINS DURING THE EARLY STAGE OF SEVERE BURNS

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Abstract
Summary: The rate of distribution of albumin and gamma‐G globulin was studied in patients with burns of varying degree by means of isotopically labeled proteins. The rate was highest in patients with extensive burns and higher the sooner the examination was made after the accident. By isotope studies using whole‐body counting the magnitude of the extravascular distribution of albumin as well as the losses of albumin from the wound surfaces were established. In cases of very extensive burns about one plasma pool of albumin was retained extravascularly during the first few days, and up to one plasma‐pool can be lost from the wound surfaces. The importance of adequate protein therapy is emphasized.