PHOSPHOLIPASE ACTIVITIES OF BRONCHOALVEOLAR LAVAGE FLUID IN RAT PNEUMOCYSTIS-CARINII PNEUMONIA

  • 1 January 1983
    • journal article
    • research article
    • Vol. 64  (1) , 75-80
Abstract
Respiratory distress, main clinical symptom of P. carinii pneumonia, is unexplained. It may be linked with a lung surfactant anomaly. In the bronchoalveolar fluid lavage of P. carinii-infected rats a very significant decrease of the phospholipid content, a lowering of the phospholipid/protein ratio; and an increase in phospholipase activities, partly due to the activation of an inactive phospholipase into the active form. Apparently, in P. carinii-infected rats, there is an increased catabolism of lung surfactant.

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