Septal lesions and behavior: Effects of presurgical rearing and strain of mouse.

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Abstract
In 2 experiments a total of 64 black C57BL/10J and 64 albino SJL/J male mice were reared in either enriched social cages or restricted individual cages from 25 days of age until they underwent septal or control surgery 1 mo later. Enrichment differentially altered septal or control behavior as measured by fluid consumption of water, saccharin, and quinine; performance on a rotorod; and the acquisition of an active avoidance task. The interactions of presurgical history with brain damage were manifested differently in the 2 strains of mice. The importance of attending more to genetic and presurgical history in attempts to define the effects of brain damage on behavior and to determine the function of brain structures is discussed. (25 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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