Inhibition of lipid peroxidation by calcium ions and their protection of steroid hydroxylase activity from peroxidative damage

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Abstract
Lipid peroxidation of adrenocortical mitochondria and microsomes was greatly stimulated by addition of 1.0 mM or less ferric ions. In the presence of NADPH-yielding system, the formation of corticosterone from endogeneous cholesterol and exogeneous deoxycorticosterone was inhibited as the concentrations of iron increased. Of interest is the fact that 0.5 mM ferric ion-mediated lipid peroxidation was completely abrogated upon addition of 2 mM calcium ions. Accordingly, the activity of corticoidogenesis was dramatically protected from the peroxidative damage.