Experimental Assessment of the Protective Activity of Diazepam on the Acute Toxicity of Chloroquine

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Abstract
The dose of diazepam that reduces the mortality rate of acute intoxications with chloroquine was determined: The oral LD50 of chloroquine (330 mg/kg) was administered and immediately thereafter diazepam was injected i.p. to male and female rats at dose levels of 2.5, 7.5, 20, 55 and 148 mg/kg. An untreated group served as control. A significant decrease of the mortality rate was observed at the dose levels 7.5, 20 and 55 mg/kg with optimal effect at 20 mg/kg. This mortality rate was analyzed by analysis of variance. The occurrence of 2 types of symptoms: convulsions and respiratory disturbances was analyzed by the chi square method.

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