Inhibition of Carcinogenesis

Publisher Website
Google Scholar
Abstract
The activity of carcinogenic hydrocarbons can be inhibited by closely related pure compounds or by crude mixtures including a spectrum of polycyclic aromatic hydrocarbons when both carcinogen and anticarcinogen are administered simultaneously. Though this effect is maximum when the agents are administered simultaneously, inhibition can also be observed when the anticarcinogen is administered several days before or after the administration of the carcinogen. Both the potency of the carcinogen and the degree of inhibition are significantly related to the vehicle used, the dose of the carcinogen, the ratio of the anticarcinogen to the carcinogen, and the structural relationship of the anticarcinogens to carcinogens. Studies on anticarcinogenesis provide one additional tool for studying mechanisms of carcinogenesis.