Subhydroxylated collagen in scleroderma
Open Access
- 1 July 1978
- journal article
- research article
- Published by Medical Journals Sweden AB in Acta Dermato-Venereologica
- Vol. 58 (4) , 359-361
- https://doi.org/10.2340/0001555558359361
Abstract
In sclerodermal skin, the values for proline (Pro), hydroxyproline (Hyp) and hydroxylsine (Hyl) are lower than in normal skin. The molar ratio Hyp to Hyl is lowered. The molar ratio Pro to Hyp was found to be elevated, while that of Pro to Hyl was like that of normal skin. It was concluded that in slceroderma the hydroxylation of Pro to Hyp is incomplete, resulting in an abnormal collagen.This publication has 4 references indexed in Scilit:
- Abnormal skin collagen in sclerodermaActa Dermato-Venereologica, 1978
- Parallel studies on collagen hydroxyproline and hydroxylysine in human skin biopsiesActa Dermato-Venereologica, 1975
- Scleroderma: Dermal Amino Acid Composition with Particular Reference to Hydroxyproline.Experimental Biology and Medicine, 1966
- A PHOTOMETRIC METHOD FOR THE DETERMINATION OF PROLINEJournal of Biological Chemistry, 1955