An integron-associated beta-lactamase (IBC-2) from Pseudomonas aeruginosa is a variant of the extended-spectrum beta-lactamase IBC-1
Open Access
- 1 November 2001
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 48 (5) , 627-630
- https://doi.org/10.1093/jac/48.5.627
Abstract
An extended-spectrum β-lactamase, IBC-2, produced by a clinical strain of Pseudomonas aeruginosa, was characterized. blaIBC-2 was found, as a gene cassette, to be the sole gene within the variable region of a class 1 integron probably located in the chromosome. IBC-2 is a variant of IBC-1 and GES-1, differing by one amino acid from each of these β-lactamases. When expressed in Escherichia coli, IBC-2 was observed to confer resistance to ceftazidime and decreased susceptibility to other oxyimino-β-lactams.Keywords
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