Effect of Cyclic AMP on Histamine Release Induced by Compound 48/80
- 1 January 1979
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 60 (4) , 461-464
- https://doi.org/10.1159/000232377
Abstract
Bu2 cAMP(N6, O2′-dibutyryl adenosine-3′,5′-cyclic monophosphate) inhibited the response of rat peritoneal mast cells to compound 48/80 in the presence of calcium ions. In the absence of calcium, the nucleotide partially prevented the desensitization induced by chelating agents. The response of cells, allowed to accumulate Bu2 cAMP in the presence of calcium (to avoid depletion of intracellular stores of the ion) and then challenged in the absence of extracellular calcium, was also inhibited. These results are discussed in terms of the postulated effects of Bu2 cAMP on the calcium-gating mechanism operative in histamine secretion.Keywords
This publication has 2 references indexed in Scilit:
- The relationship between histamine secretion and 45calcium‐uptake by mast cellsThe Journal of Physiology, 1977
- Inhibitory role of cyclic adenosine 3′5′-monophosphate in histamine release from rat peritoneal mast cells in vitroBiochemical Pharmacology, 1976