Splenic Foci of Cytotoxic Lymphocytes in a Graft-versus-Host Reaction
- 1 January 1978
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 56 (4) , 334-343
- https://doi.org/10.1159/000232039
Abstract
It has been established that cytotoxic lymphocytes are generated in discrete foci in the spleens of mice undergoing a graft-versus-host reaction. The foci segregated randomly in such spleens. 2.8 × 104 lymph node cells, 2.3 × 105 spleen cells and 2.7 × 106 thymus cells from CBA mice generated a mean of one focus in lethally irradiated (CBA × DBA)F1 recipient mice. Cytotoxic foci were detected when cytotoxicity was measured by two different cytotoxicity assays, the release of [51Cr]-sodium chromate from [51Cr]-labelled target cells and colony inhibition. The seeding efficiency of cytotoxic focus-forming cells has been estimated at 19%.Keywords
This publication has 1 reference indexed in Scilit: