Long-Term Retention of Tritiated Estradiol in Brain and Peripheral Tissues of Male and Female Rats

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Abstract
Gonadectomized male and female rats were administered tritiated estradiol intravenously and sacrificed either 2 h or 24 h later. Samples of brain cortex, hypothalamus, and pre-optic-diagonal band region were taken as were samples of pituitary, muscle, and plasma. Analysis of disintegrations/min/mg (DPM/mg) indicated a significantly greater retention of radioactivity in males than in females in all samples except pituitary. Hypothalamic, preoptic-diagonal band, and pituitary samples showed significant declines in radioactivity between 2 h and 24 h. Reanalysis of the data in terms of the ratio of tissue DPM/mg to plasma DPM/mg or to cortex DPM/mg provided quite different findings. Ratio measures failed to reveal any significant male-female differences in the retention of radioactivity. The data were taken to indicate that no simple relationship exists between genetic sex and the retention of radiolabeled estradiol.

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