Subtypes of losartan-sensitive angiotensin receptor in the rabbit pulmonary artery

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Abstract
1 The short rabbit pulmonary artery was denuded of endothelium and divided into three sections, the cardiac end (cardiac), middle and pulmonary end (pulmonary) sections, respectively. Des-Asp-angiotensin I attenuated the contractions of the cardiac and middle sections to transmural nerve stimulation but potentiated the contractions in the pulmonary section. 2 The actions of the nonapeptide were inhibited completely by 10−6 m losartan; however, a similar concentration of PD123319 had no effect. Indomethacin (10−6 m) also inhibited completely the attenuation in the cardiac and middle sections but had no effect on the potentiation seen in the pulmonary section. 3 The data suggest that the two differential responses of the pulmonary artery to des-Asp-angiotensin I are mediated by two separate subtypes of the losartan-sensitive angiotensin AT1 receptor.