Methyl 3-(triphenylphosphoranylideneamino)pyrazine-2-carboxylate: synthesis, crystal structure and use in pteridin-4(3H)ones synthesis
- 1 January 1996
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 3,p. 247-254
- https://doi.org/10.1039/p19960000247
Abstract
The title iminophosphorane 6 has been prepared from methyl 3-aminopyrazine-2-carboxylate 1 by a modified Kirsanov method using a triphenylphosphine–hexachloroethane–triethylamine system. The crystal structure of 6 illustrated an iminophosphorane function (NP bond). 2,3-Disubstituted pteridin-4(3H)-ones were obtained in a one-pot reaction of 6 with isocyanates, followed by heterocyclization on addition of alcohols or amines.Keywords
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