Discovery and structure-activity relationship of a series of 1-carba-1-dethiacephems exhibiting activity against methicillin-resistant Staphylococcus aureus
- 1 July 1993
- journal article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 36 (14) , 1971-1976
- https://doi.org/10.1021/jm00066a006
Abstract
The synthesis and antimicrobial activity of several new 1-carba-1-dethiacephalosporins is described. The discovery of unique activity of some of the analogues against methicillin-resistant Staphylococcus aureus led to the development of a structure-activity relationship designed to optimize this activity. The results of this investigation along with the pharmacokinetic characteristics of select compounds are described.Keywords
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