Fate of haem iron in the malaria parasite Plasmodium falciparum
Open Access
- 15 July 2002
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 365 (2) , 343-347
- https://doi.org/10.1042/bj20020793
Abstract
Chemical analysis has shown that Plasmodium falciparum trophozoites contain 61±2% of the iron within parasitized erythrocytes, of which 92±6% is located within the food vacuole. Of this, 88±9% is in the form of haemozoin. 57Fe-Mössbauer spectroscopy shows that haemozoin is the only detectable iron species in trophozoites. Electron spectroscopic imaging confirms this conclusion.Keywords
This publication has 17 references indexed in Scilit:
- Intraerythrocytic Plasmodium falciparum utilizes only a fraction of the amino acids derived from the digestion of host cell cytosol for the biosynthesis of its proteinsMolecular and Biochemical Parasitology, 2001
- The structure of malaria pigment β-haematinNature, 2000
- Inhibition of the peroxidative degradation of haem as the basis of action of chloroquine and other quinoline antimalarials.1999
- Quinoline anti‐malarial drugs inhibit spontaneous formation of β‐haematin (malaria pigment)FEBS Letters, 1994
- Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoitesNature, 1992
- Synchronization of Plasmodium falciparum Erythrocytic Stages in CultureJournal of Parasitology, 1979
- Human Malaria Parasites in Continuous CultureScience, 1976
- Magnetic and spectroscopic probes for FeOFe linkages in hemin systemsBioinorganic Chemistry, 1975
- Spectrophotometric determination of serum iron at the submicrogram level with a new reagent (ferrozine)Analytical Biochemistry, 1971
- THE FEEDING MECHANISM OF AVIAN MALARIAL PARASITESThe Journal of cell biology, 1966