Autoimmune and Inflammatory Mechanisms in Atherosclerosis
Top Cited Papers
- 1 April 2004
- journal article
- review article
- Published by Annual Reviews in Annual Review of Immunology
- Vol. 22 (1) , 361-403
- https://doi.org/10.1146/annurev.immunol.22.012703.104644
Abstract
The present review focuses on the concept that cellular and humoral immunity to the phylogenetically highly conserved antigen heat shock protein 60 (HSP60) is the initiating mechanism in the earliest stages of atherosclerosis. Subjecting arterial endothelial cells to classical atherosclerosis risk factors leads to the expression of HSP60 that then may serve as a target for pre-existent cross-reactive antimicrobial HSP60 immunity or bona fide autoimmune reactions induced by biochemically altered autologous HSP60. Endothelial cells can also bind microbial or autologous HSP60 via Toll-like receptors, providing another possibility for targetting adaptive or innate immunological effector mechanisms.Keywords
This publication has 211 references indexed in Scilit:
- Neopterin levels in patients with coronary artery disease are independent of chlamydia pneumoniae seropositivityAmerican Heart Journal, 2003
- Toll-like receptors and innate immunityNature Reviews Immunology, 2001
- Increased Expression and Activation of Stress-Activated Protein Kinases/c-Jun NH2-Terminal Protein Kinases in Atherosclerotic Lesions Coincide with p53The American Journal of Pathology, 2000
- The Binding of Oxidized Low Density Lipoprotein to Mouse CD36 Is Mediated in Part by Oxidized Phospholipids That Are Associated with Both the Lipid and Protein Moieties of the LipoproteinPublished by Elsevier ,2000
- Atherosclerosis—An autoimmune disease! 11This paper is a modified version of an informal article that appeared in the February 1999 issue of Immunology News of the British Society for Immunology.Experimental Gerontology, 1999
- Regression of arteriosclerotic lesions induced by immunization with heat shock protein 65-containing material in normocholesterolemic, but not hypercholesterolemic, rabbitsAtherosclerosis, 1996
- Is atherosclerosis an immunologically mediated disease?Immunology Today, 1995
- Extracellular matrix proteins in intrathymic T-cell migration and differentiation?Immunology Today, 1993
- Immunology of atherosclerosis: Cellular composition and major histocompatibility complex class II antigen expression in aortic intima, fatty streaks, and atherosclerotic plaques in young and aged human specimensClinical Immunology and Immunopathology, 1990
- Book ReviewAmbulatory Pediatric CareNew England Journal of Medicine, 1989