Effects of Cromakalim (BRL 34915) and Pinacidil on Normal and Hypertrophied Rat Detrusor in Vitro

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Abstract
Normal and hypertrophied rat detrusor were investigated in vitro with regard to effects of the K+-channel openers pinacidil and cromakalim. Both drugs abolished spontaneous contractile activity and induced a relaxation of normal and hypertrophied detrusor preparations. In both types of preparation, contractions elicited by K+, carbachol or electrical field stimulation were depressed in the presence of the K+- channel openers. Responses induced by K+ or electrical stimulation were more reduced in the hypertrophied than in the normal detrusor. Both K+-channel openers increased the efflux of 86Rb+ in a concentration-dependent way and this increase was similar in normal and hypertrophied detrusor. If applicable to man, this data suggest that K+-channel openers may be effective in the treatment of bladder instability secondary to outflow obstruction.