Cloning and Biochemical Characterization of FOX-5, an AmpC-Type Plasmid-Encoded β-Lactamase from a New York City Klebsiella pneumoniae Clinical Isolate
Open Access
- 1 November 2001
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 45 (11) , 3189-3194
- https://doi.org/10.1128/aac.45.11.3189-3194.2001
Abstract
Klebsiella pneumoniae 5064, isolated in New York, carried plasmid-mediated resistance to multiple β-lactams and was unresponsive to clavulanic acid. The β-lactamase gene responsible for cephalosporin resistance encoded FOX-5, with 96 to 97% amino acid identities to other members of the FOX family of β-lactamases. The bla FOX-5 coding region was located next to a transposase gene from the Aeromonas salmonicida insertion element IS AS2 .Keywords
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