EFFECTS OF TRANSPLANTED PITUITARY GLANDS FROM NON-ARTERIOSCLEROTIC VIRGIN AND ARTERIOSCLEROTIC BREEDER DONORS TO HYPOPHYSECTOMIZED RATS

1 October 1968

journal article
Published by Oxford University Press (OUP) in Acta Endocrinologica

Vol. 59 (2) , 249-260
https://doi.org/10.1530/acta.0.0590249

Abstract

Hypophysectomized female weanling rats were transplanted with heterotrophic pituitary glands removed from male and female virgin and breeder rats. The virgin rats were normal whereas the breeder rats had varying degrees of arteriosclerosis, hypertension, diabetes, and other degenerative diseases. The multiple ectopic pituitary glands, regardless of donor source, were equally effective in maintaining growth, thymus, adrenal, heart, kidney, and ovarian weight and serum corticosterone levels well above the hypophysectomized controls but not equal to normal controls. Histological evidence rather than gravimetric or serum corticosterone data suggests that the pituitary glands of repeatedly bred female rats may contain extra gonadotrophic and adrenocorticotrophic activity.

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