THE SUPPRESSION OF ADRENOCORTICAL SECRETION WITH 17α-ETHYL-19-NORTESTOSTERONE

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Abstract
SUMMARY: Administration of 17α-ethyl-19-nortestosterone (50–100 mg/day) to four men with peptic ulcers caused a reduction in the excretion of 17-ketosteroids and 17-ketogenic steroids. All the major urinary 17-ketosteroids were decreased by this treatment, but 11β-hydroxyandrosterone appeared to be least affected. Single injections of androst-4-ene-3:17-dione were given to one patient both before and during the period of ethyl-nortestosterone treatment. Recovery of the metabolites of androstenedione in the 48 hr following injection was virtually the same in the pretreatment and treatment periods. This was interpreted to mean that alteration of the metabolism of this adrenal steroid was not the basis of the suppression of ketosteroid excretion. It is therefore concluded that 17α-ethyl-19-nortestosterone can cause suppression of adreno-cortical secretion.