ENDOTOXIN-INDUCED CHANGES IN PLASMA-CONCENTRATIONS OF THROMBOXANE AND PROSTACYCLIN IN NEONATAL CALVES GIVEN ANTISERUM TO A MUTANT ESCHERICHIA-COLI (J-5)

  • 1 December 1986
    • journal article
    • research article
    • Vol. 47  (12) , 2520-2524
Abstract
Plasma concentrations of the stable hydrolysis products of thromboxane (Tx) A2, TxB2, and prostacyclin (6-keto-prostaglandin F1.alpha.; PGF1.alpha.) were evaluated in 22 neonatal calves given endotoxin (0.5 .mu.g/kg) by slow i.v. infusion over a 5-hour period. The effect of pretreatment with bovine antiserum to a mutant of Escherichia coli O111:B4 (J-5) on plasma concentrations of these eicosanoids was determined. Plasma concentrations of TxB2 and 6-keto-PGF1.alpha. were increased in response to endotoxin infusion. The mean plasma concentrations of TxB2 peaked 1 hour after endotoxin infusion began and was significantly increased from base line through 8 hours. Mean plasma 6-keto-PGF1.alpha. concentrations increased more slowly and was increased from base line only at 2 hours after endotoxin infusion began. Administration of bovine J-5 antiserum had no significant effect on endotoxin-induced thromboxane and prostacyclin production.