CROSS-BRIDGE PROPERTIES DERIVED FROM MUSCLE ISOTONIC VELOCITY TRANSIENTS
- 1 October 1969
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 64 (2) , 504-511
- https://doi.org/10.1073/pnas.64.2.504
Abstract
The rate constants for the turnover of cross-bridges during frog muscle contraction were determined from an analysis of the motion that follows step decreases in load. For a given projection from the myosin filament, there appears to be a range of about 100 A along the length of the filament over which the projection can attach to the actin filament and form a cross-bridge. The site of attachment is then displaced by a distance of this same order before the link is broken. The values of the rate constants also imply that a cross-bridge is formed each time an actin site comes within range of a myosin projection, so that the turnover of cross-bridges for a given contraction distance is independent of the speed of the motion.Keywords
This publication has 6 references indexed in Scilit:
- The low-angle X-ray diagram of vertebrate striated muscle and its behaviour during contraction and rigorJournal of Molecular Biology, 1967
- Tension development in highly stretched vertebrate muscle fibresThe Journal of Physiology, 1966
- The effect of load on the heat of shortening of muscleProceedings of the Royal Society of London. B. Biological Sciences, 1964
- Kinetics of Muscular Contraction : the Approach to the Steady StateNature, 1960
- An analysis of the mechanical components in frog's striated muscleThe Journal of Physiology, 1958
- Muscle Structure and Theories of ContractionProgress in Biophysics and Biophysical Chemistry, 1957