Effect of Diamfenetide on Experimental Infections of Fasciola hepatica in Lambs: Anthelmintic and Clinical Investigations

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Abstract
The activity of diamfenetide (N,N''-[oxybis(2,1-ethane diyloxy-4,1-phenylene)] bis acetamide) was studied in lambs experimentally inoculated with F. hepatica. The drug was given ora orally at a dose level of 100 mg/kg 1, 3, 5, 7 or 9 wk postinoculation. It was 100% effective 1, 3 and 5 wk postinoculation, 73% effective 7 wk postinoculation and 57% effective 9 wk postinoculation. Serum .gamma.-glutamyl transpeptidase activity remained normal in all lambs for 5 wk after infection; it then began to increase in infected, untreated lambs at 6 wk and increased 5-6-fold 9 wk postinoculation in infected lambs. This enzyme activity was the most sensitive hematologic parameter used in this test to detect hepatobiliary damage by the parasite. The drug was well tolerated at the dose level used.

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