SERUM PEPSINOGEN-I AND THE STATE OF GASTRIC-MUCOSA IN AN ESTONIAN POPULATION-SAMPLE

  • 1 January 1984
    • journal article
    • research article
    • Vol. 19  (8) , 1091-1094
Abstract
Adult subjects (77) from a rural population were examined by gastroscopic biopsy and serum pepsinogen I (PG I) determination. A new radioimmunoassay method for PG I determination, based on enzymatic iodination and the double antibody solid-phase technique, was used. A highly significant correlation (r = 0.488, P < 0.001) between the state of the fundal mucosa and the PG I level was observed. In persons with severe or moderate forms of atrophic fundal gastritis the PG I values were notably lower than those of the other groups. Good differentiation of persons with normal fundal mucosa and with severe fundal gastritis was obtained. In subjects with a normal fundal mucosa the PG I values were significantly higher in men (130 .+-. 48 .mu.g/l) than in women (87 .+-. 17 .mu.g/l). A decline in serum PG I level with age was observed. In patchy gastritis the PG I value is helpful in assessing the state of the fundal mucosa.

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