Further Observations on the Response of Birds to One Intranasal Vaccination with the B-1 Strain of Newcastle Disease Vaccine

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Abstract
Three-month-old birds, vaccinated once intranasally with the B-l strain of Newcastle disease virus (NDV), resisted intramuscular challenge for 16 months, the longest period tested. A rapid appearance of the hemagglutination inhibition (HI) and of the NDV-neutralizing antibodies was followed by a sudden decline of the HI antibodies and by a slow and irregular descent of the neutralizing antibodies. The vaccinated birds were consistently immune to challenge in spite of insigificant levels of neutralizing antibodies in 7 of the 15 birds tested.