In VitroAntifungal Activity of Triterpenoid Saponins

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Abstract
The antifungal activity of triterpenoid saponins, with hederagenin or oleanolic acid as aglycone, was investigated in vitro by the agar dilution method. Monodesmosidic hederagenin derivatives were shown to exhibit a broad spectrum of activity against yeast as well as dermatophyte species. α-Hederin was the most active Compound, and Candida glabrata was the most susceptible strain. The structure-activity relationships are discussed.

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