RATE OF HAEMOGLOBIN SYNTHESIS AFTER BLOOD LOSS IN SHEEP AND THE INFLUENCE OF DIETARY PROTEIN

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Abstract
Summary: In intact sheep a moderate degree of experimental anaemia (6 g. Hb. per cent), maintained by daily bleeding, provoked a marked increase in the rate of haemoglobin synthesis. The maximal rate of haemoglobin synthesis achieved was about 3½ times the nomal rate — equivalent to the production of 0·25 g. Hb. per day per kg. body weight. Haemoglobin concentration in blood was maintained at 6g. Hb. per cent partly at the expense of the reserve haemoglobin in the spleen. Haemodilution was observed during bleeding, followed by haemoconcentration during the recovery period.Splenectomized sleep responded to single massive bleeding or repeated daily bleeding with an increase in the rate of haemoglobin synthesis and in the retention of dietary nitrogen.Comparison of the rate of haemoglobin synthesis on two levels of protein intake (65 g. and 145 g. crude protein per sheep per day) Suggested that the rate of haemoglobin synthesis was independent of dietary protein within the limits examined, but the level of the circulating mass ol haemoglobin after recovery from bleeding was probably Influenced by the protein intake.

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