Metaiodobenzylguanidine (MIBG) labeled with 123I/131I in neuroblastoma diagnosis and follow‐up treatment with a review of the diagnostic results of the international workshop of pediatric oncology held in Rome, september 1986

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Abstract
Our experience in scintigraphic diagnosis using 123l/131l‐metaiodobenzylguanidme (MIBG) on 37 children with neuroblastomas stage III‐IV is reported and discussed, together with the results obtained by other authors on MIBG diagnosis at the International Workshop of Pediatric Oncology held in Rome in September 1986. In our own investigation, 49 examinations were undertaken with 123l‐MIBG and 66 with 131l‐MIBG partly under therapy conditions with high‐activity doses of 131I‐MIBG. There were 29 neuroblastomas, 3 ganglioneuromas, and 3 ganglioneuroblastomas. The localization of all primary tumors was over 90%; for neuroblastomas with a high level of catecholamine excretion, over 95%. The specificity was about 100%. The sensitivity with respect to tumor relapse and all localization of metastasis and bone‐marrow tumor infiltration in the followup‐phase approaches was 70% during or after therapy. What emerges from the experience of most investigators is that 123l‐MIBG is the agent best suited to detect tumor relapse and metastasis, especially in the bone marrow. MIBG examinations are of great value in follow‐up studies for detecting tumor relapse and bone marrow infiltrations, especially before the onset of clinical symptoms and other indications.

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