The apparent antipsychotic action of the 5-HT2a receptor antagonist M100907 in a mouse model of schizophrenia is counteracted by ritanserin
- 1 April 1997
- journal article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 104 (4-5) , 561-564
- https://doi.org/10.1007/bf01277672
Abstract
The apparent antipsychotic action of the selective 5-HT2a receptor antagonist M100907 in MK-801-treated NMRI mice was shown to be markedly counteracted by the 5-HT2a/2c receptor antagonist ritanserin. The mechanism of action and potential implications are discussed.Keywords
This publication has 13 references indexed in Scilit:
- Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile.1996
- The selective 5-HT2a receptor antagonist MDL 100,907 counteracts the psychomotor stimulation ensuing manipulations with monoaminergic, glutamatergic or muscarinic neurotransmission in the mouse ? implications for psychosisJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1995
- 5-HT2 receptor subtypes: A family re-united?Trends in Pharmacological Sciences, 1995
- Evidence for biochemical heterogeneity in schizophrenia: a multivariate study of monoaminergic indices in human post-mortal brain tissueJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1994
- Ritanserin, a Selective 5-HT2/1CAntagonist, and Negative Symptoms in SchizophreniaThe British Journal of Psychiatry, 1993
- Alterations in Extracellular and Tissue Levels of Biogenic Amines in Rat Brain Induced by the Serotonin2Receptor Antagonist, RitanserinJournal of Neurochemistry, 1992
- Gaps and peculiarities in 5-HT2 receptor studies.1990
- The concept of selectivity in 5-HT receptor researchEuropean Journal of Pharmacology: Molecular Pharmacology, 1990
- The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.Proceedings of the National Academy of Sciences, 1986
- RECEPTOR-BINDING PROPERTIES INVITRO AND INVIVO OF RITANSERIN - A VERY POTENT AND LONG-ACTING SEROTONIN-S-2 ANTAGONIST1985