NEUROSYPHILIS TREATED WITH PENICILLIN

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Abstract
Since the original report of Mahoney that syphilis had been successfully treated with penicillin, the management of neurosyphilis has been studied by many workers. The general trend has been a fairly revolutionary one in the direction of simplifying the treatment. Some workers advocate omitting fever in the management of neurosyphilis and some indicate that the addition of fever is useful. The use of arsenical and bismuth compounds in conjunction with penicillin salts has generally been discontinued. Since 1944 my associates and I have studied the effect of penicillin on neurosyphilis by various technics designed to determine what elements of treatment are useful and which can be safely abandoned. Even with a fairly large material, such a study must progress slowly, because the disease is one in which partial remissions often occur and relapses, even during treatment, are frequent. Numerous reports in the literature have dealt with this problem in the

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