INFLUENCE OF PAPAVERINE ON THE ENERGY-METABOLISM PROCESSES IN THE MYOCARDIAL MITOCHONDRIA

  • 1 January 1979
    • journal article
    • research article
    • Vol. 42  (2) , 132-136
Abstract
In experiments with dog myocardial mitochondria, the influence of different doses of papaverine on the succinate, glutamate and .alpha.-ketoglutarate oxidation was studied. The drug effect depended on its dose and was not related to substrate transport across the mitochondrial inner membrane block of the respiratory chain between NADH and cytochrome b. The papaverine action is possibly due to the inhibition of specific dehydrogenases. The glutamate oxidase system proves to be most sensitive to inhibition produced by papaverine, while the .alpha.-ketoglutarate oxidase system is less susceptible to the effect of this drug. The succinate oxidase system is least sensitive to the action of papaverine.

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