Systemic lambda light-chain deposition in a patient with myeloma.
- 28 February 1981
- Vol. 282 (6265) , 681-683
- https://doi.org/10.1136/bmj.282.6265.681
Abstract
Systemic lambda light-chain deposition occurred in a 73-year-old man with myeloma. An initial renal biopsy specimen showed the features of myeloma kidney. When he died 22 months later lambda light chains were detected by immunofluorescence in kidneys, liver, spleen, and heart. They were probably responsible for cardiac dysfunction and the fatal arrhythmia. It is suggested that in this patient deposition was due to a structural alteration of the light chains, possibly induced by cyclophosphamide.This publication has 9 references indexed in Scilit:
- Nonsecretory Myeloma Associated with Nodular GlomerulosclerosisActa Medica Scandinavica, 1980
- SYNTHESIS OF ABNORMAL HEAVY AND LIGHT-CHAINS IN MULTIPLE-MYELOMA WITH VISCERAL DEPOSITION OF MONOCLONAL IMMUNOGLOBULIN1980
- An evaluation of diabetic and pseudodiabetic glomerulosclerosisThe American Journal of Medicine, 1979
- Manifestations of systemic light chain depositionThe American Journal of Medicine, 1976
- Variants of Mouse Myeloma Cells That Produce Short Immunoglobulin Heavy ChainsProceedings of the National Academy of Sciences, 1974
- Immunocytoma o' mice an' men.BMJ, 1971
- Metabolism of Bence Jones Proteins in Multiple Myeloma Patients and in Patients with Renal DiseaseScandinavian Journal of Clinical and Laboratory Investigation, 1970
- THE ROLE OF THE KIDNEY IN THE CATABOLISM OF BENCE JONES PROTEINS AND IMMUNOGLOBULIN FRAGMENTSThe Journal of Experimental Medicine, 1967