Validity of contrast hyperemia for clinical assessment of coronary flow reserve: The optimal dose of contrast medium and reproducibility of the technique

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Abstract
The dose‐response relation of contrast medium‐induced hyperemic response in coronary blood flow (contrast hyperemia) was investigated to determine the optimal dose of contrast medium (CM, Urografin‐76®) for the assessment of coronary flow reserve in man. The great cardiac venous flow (GCVF) was determined with the continuous thermodilution method during the contrast hyperemia induced by the intracoronary injection of CM of three different doses, ie, 2, 4, and 6 ml/60 kg of body weight, into left coronary artery. Submaximal coronary vasodilation could be obtained by intracoronary injection of 4 ml of CM with minimal changes in systemic hemodynamics. The contrast hyperemia with this dose of CM was reproducible and also closely correlated with that obtained during pacing‐induced angina. Thus, we conclude that the contrast hyperemic technique with intracoronary injection of 4 ml of Urografin‐76® could be a reliable method to assess the coronary flow reserve.