Hepatitis-Associated Antigen in Blood Donor Populations

Abstract
Blood-donor serum samples from five medical centers, tested for hepatitis-associated antigen (HAA), showed widely varying incidence (0.06% to 1.47%). The incidence of HAA in the donor population correlated excellently with that of overt posttransfusion hepatitis. The sensitivity of the agar-gel immunodiffusion test was evaluated by study of the serum of 92 blood donors highly implicated in the transmission of hepatitis. Seventeen percent of these implicated donors were found to be HAA-positive, compared to 0.2% of 13,049 normal donors.

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