Antigen-presenting cells for Lyt-2+ cells. II. Primary mixed-lymphocyte reactions stimulated by la+ dendritic cells and la −peritoneal exudate cells
- 1 November 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in International Immunology
- Vol. 1 (5) , 517-525
- https://doi.org/10.1093/intimm/1.5.517
Abstract
Information was sought on the antigen-presenting cells (APC) required for stimulating primary mixed-lymphocyte reactions (MLR) by unprimed Lyt-2+ cells in the absence of added iymphokines. Like L3T4+ cells, Lyt-2+ cells gave very high MLR in response to H-2-different dendritic cells (DC). Surprisingly, high MLR were also elicited by thioglycollate-induced peritoneal exudate cells (PEC), including la− PEC; these cells were non-immunogenic for L3T4+ cells. Since PEC consisted almost entirely of macrophages (MΦ), the data suggest that at least two different cell types, DC and MΦ, can express APC function for unprimed Lyt-2+ cells. Since resident peritoneal MΦ and in vitro cultured PEC were poorly immunogenic, the APC function of MΦ might be limited to a subset of these cells, e.g. to immature MΦ.Keywords
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