THE EFFECT OF PARATHYROID HORMONE ON THE PERMEABILITY OF THE LENS CAPSULE TO CALCIUM

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Abstract
Pig lenses were immersed in solns. containing Ca and the rate of penetration of Ca into the lens was detd. by the degree of opalescence in the lens proteins when extracted in KC1 and exposed to u.-v. radiation and moderate heat. When parathyroid extract was added to the solns. in which the lenses were immersed the penetration of Ca into the lens was completely prevented. The low blood Ca after parathyroidectomy is apparently due to loss of Ca to the cells and the cataracts occurring after parathyroidectomy are due to a combination of 2 causes: 1, denatured lens protein if the eyes have been exposed to u.-v. radiation, and 2, greater permeability of the lens capsule to Ca in the absence of parathyroid hormone.

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