Milk Let-Down Activity of Synthetic Oxytocin (Syntocinon) and Relaxin in Lactating Rats.

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Abstract
A synthetic oxytocin, (Syntocinon, Sandoz), injected intravenously into Nembutal anesthetized lactating rats in doses of .02, .05 and .1 USP/kg a few minutes after the young had commenced to nurse resulted in milk let-down after a latent period of 5-8 seconds and seemed to persist 4-5 minutes. Amount of milk thus obtained expressed as percent litter body weight corresponded very well with data similarly obtained previously with same doses of natural oxytocin. It is concluded Syntocinon and natural oxytocin possess equivalent milk let-down activity. Relaxin injected intravenously in dose of 600-1200 Guinea Pig Units into anesthetized lactating rats failed to initiate milk let-down.

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