Interaction of subminimal inhibitory concentrations of clindamycin and Escherichia coli: effects on adhesion and polymorphonuclear leukocyte function

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Abstract
Subinhibitory concentrations (sub-MICs) of clindamycin interfere with the adhesion of Escherichia coli to buccal epithelial cells and promote phagocytosis and killing of this organism by human polymorphonuclear leukocytes (PMNLs). Adherence of E. coli grown in the presence of clindamycin, at concentrations of 2–32 mg/1, varied from 21.1 ±7.4 to 25.8±7.8 bacteria per epithelial cell (EC) (mean±S.D.) as compared with 58.3 ± 10.3 per EC when the organism was cultured in the absence of the antibiotic (PE. coli was grown in medium 199 containing no antibiotic, to 289.3±56.4 (PE. coli.